DeLorenzo R J, Freedman S D
Epilepsia. 1977 Sep;18(3):357-65. doi: 10.1111/j.1528-1157.1977.tb04978.x.
The results demonstrate that calcium and phenytoin have antagonistic actions on the net level of endogenous phosphorylation of specific rat brain proteins. These specific phosphoproteins were shown to be present in synaptosome preparations, and evidence is presented for the localization of these phosphoproteins within the presynaptic nerve terminal. The data are compatible with the hypothesis that the antagonistic actions of calcium and phenytoin on the phosphorylation of synaptosome proteins may be the underlying molecular mechanism mediating the opposing actions of these agents on the release of neurotransmitter from the presynaptic nerve terminal.
结果表明，钙和苯妥英对大鼠脑特定蛋白质的内源性磷酸化净水平具有拮抗作用。这些特定的磷蛋白存在于突触体制剂中，并且有证据表明这些磷蛋白定位于突触前神经末梢内。这些数据与以下假设相符：钙和苯妥英对突触体蛋白磷酸化的拮抗作用可能是介导这些药物对突触前神经末梢神经递质释放产生相反作用的潜在分子机制。
