Stapleton Gary E, Hamzeh Rabih, Mullins Charles E, Zellers Thomas M, Justino Henri, Nugent Alan, Nihill Michael R, Grifka Ronald G, Ing Frank F
Department of Pediatrics, Section of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA.
Catheter Cardiovasc Interv. 2009 Mar 1;73(4):557-63. doi: 10.1002/ccd.21838.
Balloon angioplasty of bifurcating pulmonary artery (PA) stenoses is often inadequate, and stent treatment often requires simultaneous implantation of two stents. This study evaluates initial results and long-term follow up of transcatheter stent placement in bifurcating PAs.
This is a retrospective review of patients (pts) who had bifurcating PA stents placed in main and lobar branches from 1993 to 2007.
Forty-nine pts had bifurcating PA stents placed at a median age of 10.9 years (range 1-43 years). The mean minimum vessel diameter increased from 5.7 +/- 2.5 mm to 11.0 +/- 3.6 mm (P < 0.001), the mean gradient across the stenoses decreased from 37.0 +/- 26.9 to 9.2 +/- 13 mm Hg (P < 0.001), whereas the mean RV:FA ratio decreased from 0.76 +/- 0.29 to 0.53 +/- 0.24 (P < 0.001). There was one death due to severe pulmonary hemorrhage. F/U data were available in 38 pts (mean duration 6.3 +/- 4.1 years, range 1.2-13.1 years). Thirty pts underwent repeat catheterizations (mean 2.3 +/- 2.2 years poststent), with 26 requiring further interventions: Fifteen had balloon angioplasty alone and 11 had additional stents placed. There were no complications at f/u catheterization. Six pts underwent further palliative surgeries, although none for repair of branch PA stenoses.
Simultaneous transcatheter placement of bifurcating PA stents provides immediate gradient relief of bifurcating stenoses in the proximal or lobar branch PAs and reduces RV systolic pressure. Further interventions can be safely performed in future procedures, and the presence of stents does not complicate future surgeries.
分叉肺动脉(PA)狭窄的球囊血管成形术往往效果不佳,而支架治疗通常需要同时植入两个支架。本研究评估经导管在分叉肺动脉中植入支架的初始结果和长期随访情况。
这是一项对1993年至2007年间在主肺动脉和叶肺动脉分支中植入分叉肺动脉支架的患者进行的回顾性研究。
49例患者植入了分叉肺动脉支架,中位年龄为10.9岁(范围1 - 43岁)。平均最小血管直径从5.7±2.5毫米增加到11.0±3.6毫米(P < 0.001),狭窄部位的平均压差从37.0±26.9降至9.2±13毫米汞柱(P < 0.001),而右心室与左心房平均比值从0.76±0.29降至0.53±0.24(P < 0.001)。有1例患者因严重肺出血死亡。38例患者有随访数据(平均随访时间6.3±4.1年,范围1.2 - 13.1年)。30例患者接受了再次导管检查(支架置入后平均2.3±2.2年),其中26例需要进一步干预:15例仅接受了球囊血管成形术,11例额外植入了支架。随访导管检查无并发症发生。6例患者接受了进一步的姑息性手术,尽管没有针对分支肺动脉狭窄修复的手术。
经导管同时植入分叉肺动脉支架可立即缓解近端或叶肺动脉分支的分叉狭窄,并降低右心室收缩压。未来的手术操作可以安全地进行进一步干预,且支架的存在不会使未来手术复杂化。