Lagente Vincent, Le Quement Catherine, Boichot Elisabeth
Université de Rennes I, INSERM U620/EA MDC, 2, avenue du Pr. Léon Bernard, 35043 Rennes Cedex, France.
Expert Opin Ther Targets. 2009 Mar;13(3):287-95. doi: 10.1517/14728220902751632.
MMPs are known to regulate the turnover of extracellular matrix and have been suggested to be important in lung disease associated with tissue remodeling. Macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling in inflammatory respiratory diseases such as chronic obstructive pulmonary diseases (COPD), including emphysema. Recent studies using MMP-12 inhibitors have demonstrated a reduction in both the inflammatory process and airspace enlargement in lung tissue.
OBJECTIVE/METHODS: This review discusses the potential involvement of MMP-12 in the pathophysiological process and proposes MMP-12 as a target for inflammatory disorders of the respiratory system.
RESULTS/CONCLUSIONS: MMP-12 plays a predominant role in the inflammatory process induced by cigarette smoke, and therefore is potentially an important therapeutic target for the treatment of COPD.
已知基质金属蛋白酶（MMPs）可调节细胞外基质的更新，并且有人提出其在与组织重塑相关的肺部疾病中起重要作用。巨噬细胞弹性蛋白酶（MMP-12）能够降解细胞外基质成分，如弹性蛋白，并参与炎症性呼吸系统疾病（如慢性阻塞性肺疾病（COPD），包括肺气肿）的组织重塑。最近使用MMP-12抑制剂的研究表明，肺部组织的炎症过程和肺泡腔扩大均有所减少。
目的/方法：本综述讨论了MMP-12在病理生理过程中的潜在作用，并提出将MMP-12作为呼吸系统炎症性疾病的一个靶点。
结果/结论：MMP-12在香烟烟雾诱导的炎症过程中起主要作用，因此可能是治疗COPD的一个重要治疗靶点。
