Abeler Vera M, Røyne Odd, Thoresen Steinar, Danielsen Håvard E, Nesland Jahn M, Kristensen Gunnar B
Division of Pathology, Radiumhospitalet, University Hospital, Oslo, Norway.
Histopathology. 2009 Feb;54(3):355-64. doi: 10.1111/j.1365-2559.2009.03231.x.
To determine the frequency and survival of the various types of uterine sarcoma in the total population of Norway and evaluate histopathological prognostic factors in order to identify risk groups.
Histopathological review of all uterine sarcoma cases reported to the Norwegian Cancer Registry during 1970-2000 was undertaken. Survival dates were provided by The Cancer Registry. Kaplan-Meier survival curves were generated. The log rank test was used for univariate analysis and a Cox proportional hazards regression model for multivariate evaluation of survival. Stage of disease was the most important prognostic factor for all tumour types. Tumour size and the mitotic index (MI) were significant prognostic factors (P < 0.0001) in leiomyosarcomas confined to the uterus and allowed for separation into three risk groups with marked differences in prognosis. The prognosis of endometrial stromal sarcomas confined to the uterus was related to MI (P < 0.0001) and tumour cell necrosis (P < 0.004). Combining these parameters allowed for separation into three risk groups with marked difference in prognosis. In adenosarcomas, tumour cell necrosis was the only significant prognostic factor.
There are marked differences in survival between uterine sarcoma types. Leiomyosarcomas and endometrial stromal sarcomas can be divided into different groups.
确定挪威总人口中各类子宫肉瘤的发病率及生存率，并评估组织病理学预后因素以识别风险组。
对1970 - 2000年间向挪威癌症登记处报告的所有子宫肉瘤病例进行组织病理学复查。生存日期由癌症登记处提供。生成了Kaplan - Meier生存曲线。采用对数秩检验进行单因素分析，并使用Cox比例风险回归模型对生存情况进行多因素评估。疾病分期是所有肿瘤类型最重要的预后因素。肿瘤大小和有丝分裂指数（MI）是局限于子宫的平滑肌肉瘤的显著预后因素（P < 0.0001），并可据此分为三个预后有显著差异的风险组。局限于子宫的子宫内膜间质肉瘤的预后与MI（P < 0.0001）和肿瘤细胞坏死（P < 0.004）有关。综合这些参数可分为三个预后有显著差异的风险组。在腺肉瘤中，肿瘤细胞坏死是唯一显著的预后因素。
子宫肉瘤各类型之间的生存率存在显著差异。平滑肌肉瘤和子宫内膜间质肉瘤可分为不同的组。
