Nagayama Y, Sakurai N
Department of Pediatrics, Chiba Children's Hospital, Japan.
Pediatr Pulmonol. 1991;11(1):44-8. doi: 10.1002/ppul.1950110108.
To examine if the occurrence of wheezing among children with lower respiratory tract infections is associated with atopic predisposition, serum levels of IgE were determined for groups of children with or without wheezing, during infection with Mycoplasma pneumoniae or respiratory syncytial virus (RSV). In M. pneumoniae infection, more than 60% of wheezy children over 2 years of age showed a high IgE level (200 IU/mL or more), while IgE levels were less than 200 IU/mL in 73% of non-wheezy children. In RSV infection, the incidence of high IgE levels among wheezy children was nearly double that of non-wheezy children, although the difference was not significant. These results suggest that in children an allergic disposition is involved in the occurrence of wheezing during the course of lower respiratory tract infections.
为了研究下呼吸道感染患儿喘息的发生是否与特应性易感性有关，我们测定了肺炎支原体或呼吸道合胞病毒（RSV）感染期间有或无喘息的儿童组的血清IgE水平。在肺炎支原体感染中，超过60%的2岁以上喘息儿童IgE水平较高（200 IU/mL或更高），而73%的无喘息儿童IgE水平低于200 IU/mL。在RSV感染中，喘息儿童中高IgE水平的发生率几乎是非喘息儿童的两倍，尽管差异不显著。这些结果表明，在儿童中，过敏体质与下呼吸道感染过程中喘息的发生有关。
