评估合成鞘脂类似物作为过氧化物酶体增殖物激活受体的配体。
Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors.
作者信息
Tsuji Kiyomi, Satoh Shigeru, Mitsutake Susumu, Murakami Itsuo, Park Jeong-Ju, Li Qian, Chang Young-Tae, Chung Sung-Kee, Igarashi Yasuyuki
机构信息
Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Nishi 11, Kita 21, Kita-ku, Sapporo 001-0021, Japan.
出版信息
Bioorg Med Chem Lett. 2009 Mar 15;19(6):1643-6. doi: 10.1016/j.bmcl.2009.02.004. Epub 2009 Feb 7.
In this Letter, we assessed newly synthesized sphingolipid analogs as ligands for peroxisome proliferator-activated receptor (PPAR)alpha, PPARbeta or PPARgamma, using a dual-luciferase reporter system. We tested 640 sphingolipid analogs for ligand activity. As a result, seven types: A9, B9, C9, C50, F66, G66 and H66, were found to show agonistic activities for PPARs.
在本信函中，我们使用双荧光素酶报告系统评估了新合成的鞘脂类似物作为过氧化物酶体增殖物激活受体（PPAR）α、PPARβ或PPARγ的配体。我们测试了640种鞘脂类似物的配体活性。结果发现，七种类型：A9、B9、C9、C50、F66、G66和H66，对PPARs表现出激动活性。
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