Refsahl K, Andersen B M
Medisinsk avd, Sentralsyke-huset i Akershus, Nordbyhagen.
Nord Med. 1991;106(8-9):228-31.
131 coagulase-negative staphylococci (CNS) of clinical significance were investigated during the period 1989-1990 in Northern Norway. The staphylococci were isolated from blood cultures (68/131, 51.9 per cent), vascular catheters (6/131), patients with osteomyelitis (13/131), postoperative and other wounds (15/131) and urinary tract infections (29/131). The staphylococci were mostly from hospitalized patients (114/131). Vitek's GPI and Rosco's Staph-zym both gave a primarily correct identification in 95 per cent of the cases. S epidermidis was the predominant species (96/131; 73.3 per cent). Methicillin resistance (MR) was found in 30.5 per cent (40/131) of all CNS and in 35.4 per cent (34/96) of S epidermidis. Methicillin resistant S epidermidis isolates were usually resistant to gentamicin (25/34, 73.5 per cent). S haemolyticus was the most resistant species with MR in 5/7 strains. MR imply resistance to all beta-lactam antibiotics, including imipenem. Among S epidermidis, an increased MR from 10 per cent in 1987 to 35.4 per cent in 1989-1990 was observed. All strains were sensitive to vancomycin and rifampicin.
1989年至1990年期间，对挪威北部131株具有临床意义的凝固酶阴性葡萄球菌（CNS）进行了研究。这些葡萄球菌分离自血培养物（68/131，51.9%）、血管导管（6/131）、骨髓炎患者（13/131）、术后及其他伤口（15/131）和尿路感染（29/131）。这些葡萄球菌大多来自住院患者（114/131）。Vitek的GPI和Rosco的葡萄球菌酶试剂在95%的病例中都给出了基本正确的鉴定结果。表皮葡萄球菌是主要菌种（96/131；73.3%）。在所有CNS中，30.5%（40/131）发现有耐甲氧西林（MR），在表皮葡萄球菌中这一比例为35.4%（34/96）。耐甲氧西林的表皮葡萄球菌分离株通常对庆大霉素耐药（25/34，73.5%）。溶血葡萄球菌是耐药性最强的菌种，7株中有5株耐甲氧西林。耐甲氧西林意味着对所有β-内酰胺类抗生素耐药，包括亚胺培南。在表皮葡萄球菌中，观察到耐甲氧西林率从1987年的10%上升到1989年至1990年的35.4%。所有菌株对万古霉素和利福平敏感。
