Kelm Sebastian, Shi Jiye, Deane Charlotte M
Department of Statistics, University of Oxford, Oxford, UK.
Bioinformatics. 2009 Apr 15;25(8):1086-8. doi: 10.1093/bioinformatics/btp102. Epub 2009 Feb 23.
iMembrane is a homology-based method, which predicts a membrane protein's position within a lipid bilayer. It projects the results of coarse-grained molecular dynamics simulations onto any membrane protein structure or sequence provided by the user. iMembrane is simple to use and is currently the only computational method allowing the rapid prediction of a membrane protein's lipid bilayer insertion. Bilayer insertion data are essential in the accurate structural modelling of membrane proteins or the design of drugs that target them.
iMembrane是一种基于同源性的方法,可预测膜蛋白在脂质双分子层中的位置。它将粗粒度分子动力学模拟的结果投影到用户提供的任何膜蛋白结构或序列上。iMembrane使用简便,是目前唯一能够快速预测膜蛋白脂质双分子层插入情况的计算方法。双分子层插入数据对于膜蛋白的精确结构建模或针对它们的药物设计至关重要。