OPM：膜中蛋白质方向数据库
OPM: orientations of proteins in membranes database.
作者信息
Lomize Mikhail A, Lomize Andrei L, Pogozheva Irina D, Mosberg Henry I
机构信息
College of Literature, Science and the Arts, University of Michigan, Ann Arbor, MI 48109-1065, USA.
出版信息
Bioinformatics. 2006 Mar 1;22(5):623-5. doi: 10.1093/bioinformatics/btk023. Epub 2006 Jan 5.
SUMMARY
The Orientations of Proteins in Membranes (OPM) database provides a collection of transmembrane, monotopic and peripheral proteins from the Protein Data Bank whose spatial arrangements in the lipid bilayer have been calculated theoretically and compared with experimental data. The database allows analysis, sorting and searching of membrane proteins based on their structural classification, species, destination membrane, numbers of transmembrane segments and subunits, numbers of secondary structures and the calculated hydrophobic thickness or tilt angle with respect to the bilayer normal. All coordinate files with the calculated membrane boundaries are available for downloading.
AVAILABILITY
摘要
膜蛋白方向（OPM）数据库收集了来自蛋白质数据库的跨膜蛋白、单拓扑蛋白和外周蛋白，这些蛋白在脂质双分子层中的空间排列已通过理论计算得出，并与实验数据进行了比较。该数据库允许根据膜蛋白的结构分类、物种、目标膜、跨膜片段和亚基数量、二级结构数量以及相对于双分子层法线计算出的疏水厚度或倾斜角度对其进行分析、分类和搜索。所有带有计算出的膜边界的坐标文件均可下载。
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