Kuczynski B, Jagust W, Chui H C, Reed B
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Neurology. 2009 Feb 24;72(8):738-43. doi: 10.1212/01.wnl.0000343005.35498.e5.
To investigate associations between vascular risk profile and cerebral glucose metabolism.
Subjects ranged from normal to having dementia (age >55 years) and underwent neuropsychological testing, MRI, and FDG PET scanning (n = 58). The Framingham Cardiovascular Risk Profile (FCRP) and its individual components were used as covariates in regression analyses with each PET scan using SPM2.
Analyses revealed broad areas of the frontal lobe in which higher FCRP was associated with lower normalized glucose metabolism including the superior medial frontal, superior frontal and superior orbital frontal cortex and the ventrolateral prefrontal cortex. Significant associations were predominately found in the left hemisphere. Independent component analyses revealed interesting regions but further confirm the relevance of the integrative measure of coronary risk.
Although the mechanism of this association bears further investigation, this finding provides further evidence that vascular risk factors have malignant effects on the brain, particularly in the prefrontal cortex.
研究血管风险概况与脑葡萄糖代谢之间的关联。
受试者年龄大于55岁，涵盖从正常到患有痴呆症的人群，接受了神经心理学测试、MRI和FDG PET扫描（n = 58）。使用Framingham心血管风险概况（FCRP）及其各个组成部分作为协变量，通过SPM2对每次PET扫描进行回归分析。
分析显示额叶的广泛区域中，较高的FCRP与较低的标准化葡萄糖代谢相关，包括额上内侧、额上和额眶上皮质以及腹外侧前额叶皮质。显著关联主要在左半球发现。独立成分分析揭示了有趣的区域，但进一步证实了冠状动脉风险综合测量的相关性。
尽管这种关联的机制有待进一步研究，但这一发现提供了进一步的证据，表明血管危险因素对大脑有恶性影响，尤其是在前额叶皮质。
