[天津市中老年人群血清同型半胱氨酸水平与认知功能的调查]

[A survey on serum homocysteine levels and cognitive function of the middle-aged and elderly persons in Tianjin city].

作者信息

Kong Haiyan, Jiang Yugang, Huang Chengyu, Fang Hengtong

机构信息

West China School of Public Health, Sichuan University, Chengdu 610041, China.

出版信息

Wei Sheng Yan Jiu. 2008 Nov;37(6):677-9.

PMID:19239000

Abstract

OBJECTIVE

To explore the serum homocysteine levels and cognitive function status of the middle-aged and elderly persons in Tianjin city in order to provide fundamental data for the nutritional intervention trial.

METHODS

The subjects between the ages of 55 and 94 years were randomly recruited in the study. The cognitive function of the subjects were evaluated by the Mini Mental State Examination (MMSE), and then screened the subjects with cognitive impairment (CI). Total homocysteine (tHcy) levels in fasting serum were measured by enzyme transition method, the correlation between tHcy levels and the cognitive function were statistically analyzed.

RESULTS

The mean of serum tHcy levels were (15.95 +/- 7.29) micromol/L, the prevalence of hyperhomocysteinemia (HHE) was 45.4%; and man had a higher rates than woman ( P < 0.001); the mean MMSE scores were (26.74 +/- 2.71) points, the prevalence of CI was 26.0%, and there were no significant differences between man and woman in CI prevalence. Cognitive function status was positively correlated with education and negatively correlated with age.

CONCLUSION

It was remarkable that higher prevalence of HHE and CI existed in the middle-aged and elderly persons.

摘要

目的

探讨天津市中老年人血清同型半胱氨酸水平及认知功能状况，为营养干预试验提供基础数据。

方法

随机选取年龄在55至94岁之间的受试者。采用简易精神状态检查表（MMSE）评估受试者的认知功能，进而筛选出认知障碍（CI）患者。采用酶转化法测定空腹血清总同型半胱氨酸（tHcy）水平，对tHcy水平与认知功能之间的相关性进行统计学分析。

结果

血清tHcy水平均值为（15.95±7.29）μmol/L，高同型半胱氨酸血症（HHE）患病率为45.4%；男性患病率高于女性（P<0.001）；MMSE平均得分为（26.74±2.71）分，CI患病率为26.0%，CI患病率在男性和女性之间无显著差异。认知功能状况与受教育程度呈正相关，与年龄呈负相关。