[莫斯科人群中胰岛素酶基因多态性与2型糖尿病的关联]
[Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population].
作者信息
Slominskiĭ P A, Pivovarova O V, Shadrina M I, Artem'eva A V, Pfaipffer F G, Rudovich N N, Agadzhanian S E, Pronin V S, Limborskaia S A
出版信息
Genetika. 2009 Jan;45(1):127-31.
Association of 13 single nucleotide polymorphisms (SNPs) of insulinase (IDE) gene with type 2 diabetes mellitus (T2D) in the Moscow population has been examined. Three polymorphic markers (rs7078413, rs7899603, and rs551266) associated with the risk of T2D development have been revealed. Allele and genotype frequency distribution for these three markers differed significantly only in the sample of females between T2D patients and control individuals, while only in case of rs7078413 SNP genotype frequencies varied significantly in the total population.
已对莫斯科人群中胰岛素酶（IDE）基因的13个单核苷酸多态性（SNP）与2型糖尿病（T2D）的关联进行了研究。已发现三个与T2D发生风险相关的多态性标记（rs7078413、rs7899603和rs551266）。这三个标记的等位基因和基因型频率分布仅在T2D患者和对照个体的女性样本中有显著差异，而仅在rs7078413 SNP的情况下，基因型频率在总人群中有显著变化。
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