Cheong Sun Hee, Cho Hyeongjin, Chang Kyung Ja
Department of Food and Nutrition, Inha University, Incheon, Korea.
Adv Exp Med Biol. 2009;643:381-8. doi: 10.1007/978-0-387-75681-3_39.
The purpose of this study was to investigate the effect of protein tyrosine phosphatase 1B (PTP1B) inhibitors and taurine on blood lipid profiles of the obese adolescent. Three week-old thirty-six male Sprague-Dawley rats were randomly assigned to six groups (high fat diet (HFD) group, HFD group; high fat diet + taurine group, HFD + taurine (TR) group; high fat diet + PTP1B inhibitor A (A) group, HF + A group; high fat diet + PTP1B inhibitor B, HF + B group; high fat diet + PTP1B inhibitor A + taurine group, HF + A + TR group; and high fat diet + PTP1B inhibitor B + taurine group, HF+B+TR group). The body weight of the HF+A and HF + A + TR groups were significantly reduced compared to those of the other groups, the exception being the HF + B + TR group. Serum triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels of the HF + A + TR group were significantly reduced compared to those of the other groups. However, serum high density lipoprotein cholesterol (HDL-C) levels in HF + B + TR group was significantly reduced compared those of the HFD and HF + TR groups. Therefore, these results suggest a possible effect of PTP1B inhibitors and taurine on blood triglyceride, total cholesterol and low density lipoprotein cholesterol in the obese adolescent.
本研究的目的是调查蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂和牛磺酸对肥胖青少年血脂谱的影响。将三周龄的36只雄性Sprague-Dawley大鼠随机分为六组（高脂饮食（HFD）组；高脂饮食+牛磺酸组，HFD+牛磺酸（TR）组；高脂饮食+PTP1B抑制剂A（A）组，HF+A组；高脂饮食+PTP1B抑制剂B组，HF+B组；高脂饮食+PTP1B抑制剂A+牛磺酸组，HF+A+TR组；高脂饮食+PTP1B抑制剂B+牛磺酸组，HF+B+TR组）。与其他组相比，HF+A组和HF+A+TR组的体重显著降低，但HF+B+TR组除外。与其他组相比，HF+A+TR组的血清甘油三酯（TG）、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平显著降低。然而，HF+B+TR组的血清高密度脂蛋白胆固醇（HDL-C）水平与HFD组和HF+TR组相比显著降低。因此，这些结果表明PTP1B抑制剂和牛磺酸可能对肥胖青少年的血液甘油三酯、总胆固醇和低密度脂蛋白胆固醇有影响。
