牛磺酸可使长期摄入酒精的大鼠体内硒、铬和锰的血液水平及尿排泄量恢复正常。

Taurine normalizes blood levels and urinary loss of selenium, chromium, and manganese in rats chronically consuming alcohol.

作者信息

Park Taesun, Cho Keunsook, Park Sung-Hee, Lee Dong-Hee, Kim Ha Won

机构信息

Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Korea.

出版信息

Adv Exp Med Biol. 2009;643:407-14. doi: 10.1007/978-0-387-75681-3_42.

DOI:10.1007/978-0-387-75681-3_42

PMID:19239172

Abstract

The present study was undertaken to evaluate effects of dietary taurine supplementation on the homeostasis of trace elements, including Se, Cu, Mn and Cr, in rats chronically consuming alcohol. Male SD rats were fed for 8 wk a liquid form of a control diet (CD), an ethanol diet (ED), or a taurine-supplemented ethanol diet (TED). Plasma Se and Mn concentrations were significantly lower in the ED rats than in the CD rats; dietary taurine supplementation corrected alcohol-induced decreases in plasma Se and Mn levels. Chronic alcohol consumption significantly increased urinary excretion of Se (a 53% increase, p < 0.05), Cr (a 62% increase, p < 0.05), Mn (a 45% increase, p < 0.05) and Cu (a 30% increase, p < 0.05) in rats. Urinary losses of these trace elements induced by chronic alcohol consumption in rats were abolished by taurine supplementation. These results suggest that taurine supplementation in rats may protect against Se, Cr and Mn insufficiency caused by chronic alcohol-mediated loss of the trace elements in the urine.

摘要

本研究旨在评估补充膳食牛磺酸对长期摄入酒精的大鼠体内微量元素（包括硒、铜、锰和铬）稳态的影响。将雄性SD大鼠分别用对照饮食（CD）、乙醇饮食（ED）或补充牛磺酸的乙醇饮食（TED）的液体形式喂养8周。ED组大鼠血浆中的硒和锰浓度显著低于CD组大鼠；补充膳食牛磺酸可纠正酒精引起的血浆硒和锰水平降低。长期摄入酒精显著增加了大鼠尿液中硒（增加53%，p < 0.05）、铬（增加62%，p < 0.05）、锰（增加45%，p < 0.05）和铜（增加30%，p < 0.05）的排泄。补充牛磺酸可消除长期摄入酒精引起的大鼠这些微量元素的尿流失。这些结果表明，在大鼠中补充牛磺酸可能预防因长期酒精介导的尿液中微量元素流失而导致的硒、铬和锰缺乏。