氯化钙对异氟烷麻醉小马单次注射依诺昔酮的心肺效应的影响。

Influence of calcium chloride on the cardio-respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies.

作者信息

Schauvliege Stijn, Van den Eede Annelies, Duchateau Luc, Pille Frederik, Vlaminck Lieven, Gasthuys Frank

机构信息

Department of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium.

出版信息

Vet Anaesth Analg. 2009 Mar;36(2):101-9. doi: 10.1111/j.1467-2995.2008.00435.x.

DOI:10.1111/j.1467-2995.2008.00435.x

PMID:19239648

Abstract

OBJECTIVE

To investigate the influence of calcium chloride (CaCl(2)) on the cardio-respiratory effects of enoximone in isoflurane anaesthetized ponies.

STUDY DESIGN

Prospective consecutive experimental trial. Animals Six healthy ponies, weighing 287 +/- 55 kg were included in this study.

METHODS

After sedation (romifidine, 80 microg kg(-1)), anaesthesia was induced with midazolam (0.06 mg kg(-1)) and ketamine (2.2 mg kg(-1)) and maintained with isoflurane in oxygen. The ponies' lungs were ventilated to maintain normocapnia. After 90 minutes, a bolus of enoximone (0.5 mg kg(-1)) was administered, followed by a CaCl(2) infusion (0.5 mg kg(-1) minute(-1) over 10 minutes) (treatment EC). Sodium, potassium, ionized and total calcium concentrations, cardiovascular variables and blood-gases were measured in the 120 minutes after treatment. Using a mixed model anova, the results were compared to those of a previous report [Vet Anaesth Analg, 34 (2007) 416], evaluating the effects of 0.5 mg kg(-1) enoximone in the same ponies and under identical circumstances (treatment E). Both an overall comparison and comparisons at specific time points after treatment were performed (alpha = 0.05).

RESULTS

Although ionized and total calcium concentrations were higher during treatment EC, the cardio-respiratory effects of enoximone were comparable for both treatments. A small but significant difference in packed cell volume was detected.

CONCLUSIONS AND CLINICAL RELEVANCE

Calcium chloride did not enhance the effects of enoximone in normocalcaemic anaesthetized ponies.

摘要

目的

研究氯化钙（CaCl₂）对异氟烷麻醉的小马体内依诺昔酮心肺效应的影响。

研究设计

前瞻性连续实验性试验。动物本研究纳入了 6 匹健康小马，体重为 287±55 千克。

方法

在给予镇静剂（罗米芬定，80 微克/千克）后，用咪达唑仑（0.06 毫克/千克）和氯胺酮（2.2 毫克/千克）诱导麻醉，并用异氟烷在氧气中维持麻醉。使小马的肺通气以维持正常碳酸血症。90 分钟后，给予一剂依诺昔酮（0.5 毫克/千克），随后进行氯化钙输注（0.5 毫克/千克·分钟⁻¹，持续 10 分钟）（治疗组 EC）。在治疗后的 120 分钟内测量钠、钾、离子钙和总钙浓度、心血管变量和血气。使用混合模型方差分析，将结果与之前的一份报告[《兽医麻醉与镇痛》，34（2007）416]进行比较，该报告评估了在相同小马和相同情况下 0.5 毫克/千克依诺昔酮的效果（治疗组 E）。进行了总体比较以及治疗后特定时间点的比较（α = 0.05）。