Ball H A, Samaan Z, Brewster S, Craddock N, Gill M, Korszun A, Maier W, Middleton L, Mors O, Owen M J, Perry J, Preisig M, Rice J, Rietschel M, Jones L, Jones I, Farmer A E, McGuffin P
Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK.
Cephalalgia. 2009 Aug;29(8):848-54. doi: 10.1111/j.1468-2982.2008.01808.x. Epub 2009 Feb 23.
Migraine is frequently comorbid with depression. There appear to be common aetiological factors for both disorders, but the aetiology of migraine within depressed patients, in particular the significance of aura, has been little studied. A large sample of concordantly depressed sibling pairs [the Depression-Network (DeNT) sample] was assessed as having migraine with aura (MA), migraine without aura (MoA), probable migraine or no migraine according to International Headache Society guidelines. Correlations between siblings' migraine status were used to assess the nature of familial liability to migraine. A multiple threshold isocorrelational model fit best, in which different syndromes are conceptualized as different severities of one underlying dimension rather than as having separate aetiologies. Thus, MA and MoA were found to be different forms of the same disorder, with MA occupying the more extreme end of the spectrum of liability. Implications for our understanding of the relationship between migraine and depression are discussed.
偏头痛常与抑郁症共病。这两种疾病似乎存在共同的病因，但抑郁症患者中偏头痛的病因，尤其是先兆的意义，鲜有研究。根据国际头痛协会的指南，对大量同患抑郁症的同胞对样本（抑郁症网络样本）进行评估，确定其患有伴先兆偏头痛（MA）、无先兆偏头痛（MoA）、可能的偏头痛或无偏头痛。利用同胞间偏头痛状态的相关性来评估偏头痛家族易感性的性质。多重阈值等相关模型拟合效果最佳，其中不同综合征被概念化为一个潜在维度的不同严重程度，而非具有不同病因。因此，发现MA和MoA是同一疾病的不同形式，MA处于易感性谱的更极端一端。文中讨论了这一发现对我们理解偏头痛与抑郁症关系的启示。
