Barkova E N, Lebedeva K A, Ashikhmina E P
Department of Pathophysiology, Department of Childhood Diseases, Pediatric Faculty, Tyumen State Medical Academy, Russia.
Bull Exp Biol Med. 2008 Sep;146(3):297-300. doi: 10.1007/s10517-008-0274-4.
Circadian dynamics of ferritin, serum iron, and MDA concentrations, ineffective, normal, and terminal kinetic populations of the erythron were studied in healthy girls aged 7-9 years and girls suffering from chronic pyelonephritis. The production of highly active macrocyte population, descending from terminal erythropoiesis, was increased during pyelonephritis remission, which determined reduction of serum iron concentration during the morning hours and leveling of its circadian rhythm because of high utilization of the trace element. Progressive reduction of erythrocyte count and hemoglobin content during the active phase of pyelonephritis correlated with the increase in the population of microcytes with low activity of glucose-6-phosphate dehydrogenase and short life span, paralleled by an appreciable increase in ferritin and MDA concentrations during the evening hours. Stimulation of alternative erythron kinetic types (terminal and ineffective) underlies these changes.
对7至9岁健康女孩以及患有慢性肾盂肾炎的女孩的铁蛋白、血清铁和丙二醛浓度的昼夜动态变化、红细胞生成的无效、正常和终末动力学群体进行了研究。在肾盂肾炎缓解期，源自终末红细胞生成的高活性大红细胞群体的产生增加，这导致早晨血清铁浓度降低，并且由于微量元素的高利用率，其昼夜节律趋于平稳。在肾盂肾炎活动期，红细胞计数和血红蛋白含量的逐渐降低与葡萄糖-6-磷酸脱氢酶活性低且寿命短的小红细胞群体的增加相关，同时在傍晚时分铁蛋白和丙二醛浓度明显增加。这些变化的基础是替代红细胞生成动力学类型（终末和无效）的刺激。
