Granzhan Anton, Ihmels Heiko, Jäger Katharina
University of Siegen, Organic Chemistry, Adolf-Reichwein-Str. 2, D-57068 Siegen, Germany.
Chem Commun (Camb). 2009 Mar 14(10):1249-51. doi: 10.1039/b812891j. Epub 2009 Jan 15.
It is demonstrated that even unsubstituted cationic ligands, namely the known diazoniadibenzochrysenes (, ) and the so far unreported tetraazoniapentaphenopentaphene (), stabilize quadruplex DNA upon association; the ligand exhibits essentially the same affinity towards the quadruplex as does 5,10,15,20-tetrakis(1-methyl-4-pyridyl)-21H,23H-porphine, however, with a significantly higher selectivity for quadruplex relative to duplex DNA.
