Razi Ali, Yahyazadeh Seyed Reza, Sedighi Gilani Mohammad Ali, Kazemeyni Seyed Mohammad
Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Urol J. 2009 Winter;6(1):23-6; discussion 26.
Bladder neck-sparing modification of radical retropubic prostatectomy has been reported to lower the risk of urinary incontinence after prostatectomy. We reviewed the outcomes in men with prostate cancer who had undergone prostatectomy with either bladder neck preservation or bladder neck reconstruction.
In this retrospective study, a total of 103 patients who had undergone radical retropubic prostatectomy were assessed. The patients were divided into two groups of bladder neck preservation (51 patients) and bladder neck reconstruction (52 patients). We compared frequency of biochemical failure, bladder neck stricture, and urinary incontinence between these two groups. Biochemical failure was defined as a serum prostate-specific antigen level higher than 0.2 ng/mL and its rising trend in at least 2 postoperative subsequent measurements. Continence was defined as no need to use sanitary pads or diapers.
The two groups were comparable in terms of age, serum prostate-specific antigen level, Gleason score, and prostate volume. After a mean follow-up period of 32.5 months, all patients with bladder neck preservation and 46 (88.5%) with bladder neck reconstruction were continent (P = .03). There were no significant differences in the frequency of biochemical failure and bladder neck stricture that required dilation between the two groups of patients.
Bladder neck preservation during radical retropubic prostatectomy may improve long-term results of urinary continence and be effective in eradicating prostate cancer without increasing recurrence rate.
据报道,耻骨后根治性前列腺切除术的保留膀胱颈改良术可降低前列腺切除术后尿失禁的风险。我们回顾了接受保留膀胱颈或膀胱颈重建前列腺切除术的前列腺癌男性患者的治疗结果。
在这项回顾性研究中,共评估了103例行耻骨后根治性前列腺切除术的患者。患者被分为保留膀胱颈组(51例)和膀胱颈重建组(52例)。我们比较了两组之间生化复发、膀胱颈狭窄和尿失禁的发生率。生化复发定义为血清前列腺特异性抗原水平高于0.2 ng/mL,且在术后至少2次后续测量中有上升趋势。控尿定义为无需使用卫生巾或尿布。
两组在年龄、血清前列腺特异性抗原水平、Gleason评分和前列腺体积方面具有可比性。平均随访32.5个月后,所有保留膀胱颈的患者和46例(88.5%)膀胱颈重建的患者均能控尿(P = 0.03)。两组患者生化复发和需要扩张的膀胱颈狭窄发生率无显著差异。
耻骨后根治性前列腺切除术期间保留膀胱颈可能会改善长期尿控结果,并且在不增加复发率的情况下有效根除前列腺癌。