Mu Hao-Fang, Chen Feng, Xiong Xin, Zhang Bo, Yan Chun-Xia, Chen Teng, Deng Ya-Jun
Center of Forensic Sciences, Beijing Genomics Institute, Beijing 101300, China.
Fa Yi Xue Za Zhi. 2008 Dec;24(6):417-22.
To study sequence polymorphism of mtDNA control region in Chinese Qinghai Tibetan group and Han population.
Venous blood samples from 69 unrelated Qinghai Tibetans and Han individuals were collected and their mtDNA control region sequences were analyzed. Polymorphism indicators were calculated. The genetic distances based on Fst and Rst among eleven groups from different districts include the Qinghai Tibetan and Han population were elucidated using Nei's method. Phylogenetic tree was constructed.
There were 56 polymorphic loci and 59 loci found in the mtDNA control region of Tibetan group and Han population, respectively. It was indicated by the Rst distance that there was a far distance between Qinghai Tibetan and the other populations (P<0.05), and the distance was much closer between Qinghai Han and Xi'an Han, Mongolian, Changsha Han populations (P>0.05).
There is unique genetic polymorphism of mtDNA control region both in Qinghai Tibetan and Han population. These findings may be useful in forensic identification, population genetic and migration studies.
研究中国青海藏族群体和汉族群体线粒体DNA控制区的序列多态性。
采集69名无亲缘关系的青海藏族和汉族个体的静脉血样本，分析其线粒体DNA控制区序列。计算多态性指标。采用Nei氏方法阐明基于Fst和Rst的来自不同地区的11个群体（包括青海藏族和汉族群体）之间的遗传距离。构建系统发育树。
藏族群体和汉族群体的线粒体DNA控制区分别发现56个和59个多态位点。Rst距离表明，青海藏族与其他群体之间距离较远（P<0.05），而青海汉族与西安汉族、蒙古族、长沙汉族群体之间距离较近（P>0.05）。
青海藏族和汉族群体的线粒体DNA控制区均存在独特的遗传多态性。这些发现可能有助于法医鉴定、群体遗传学和迁徙研究。
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