Vazquez M, Miller D C, Epstein F, Allen J C, Budzilovich G N
Department of Pathology, Rita and Stanley Kaplan Cancer Center, New York University Medical Center, New York.
Mod Pathol. 1991 Jul;4(4):519-23.
Three children had central nervous system tumors with histologic and ultrastructural features corresponding to those of tumors previously described as "gliofibromas." These features, which include a composite appearance with glial and mesenchymal elements, with glial fibrillary acidic protein (GFAP)-containing and GFAP-immunonegative cells, diffuse S-100 immunoreactivity, and basal lamina wrapping processes of both cell types, suggest that the "mesenchymal" cells are Schwann cells, not fibroblasts. We therefore propose to rename this entity "glioneurofibroma." The clinical behavior of these lesions is uncertain but is more often indolent or benign.
三名儿童患有中枢神经系统肿瘤，其组织学和超微结构特征与先前描述为“胶质纤维瘤”的肿瘤特征相符。这些特征包括具有神经胶质和间充质成分的复合外观、含有胶质纤维酸性蛋白（GFAP）的细胞和GFAP免疫阴性细胞、弥漫性S-100免疫反应性以及两种细胞类型的基底膜包裹过程，这表明“间充质”细胞是施万细胞，而非成纤维细胞。因此，我们建议将这一实体重新命名为“胶质神经纤维瘤”。这些病变的临床行为尚不确定，但通常较为惰性或呈良性。
