Stein Paul D, Matta Fadi, Yaekoub Abdo Y
St. Joseph Mercy Oakland Hospital, Pontiac, Michigan 48341-5023, USA.
J Womens Health (Larchmt). 2009 Mar;18(3):327-9. doi: 10.1089/jwh.2008.0974.
To determine the incidence of amniotic fluid embolism and the incidence as modified by cesarean section and age.
Data are from the National Hospital Discharge Survey. We examined the number of patients discharged from short-stay nonfederal hospitals throughout the United States, from 1980 through 2005, with a diagnostic code for amniotic fluid embolism.
From 1980 through 2005, there were 112,712,000 deliveries, of which 12,000 patients (11/100,000) had amniotic fluid embolism. The incidence of amniotic fluid embolism was lower in 1993-2005 than in 1980-1992 (9/100,000 vs. 12/100,000)(p < 0.0001). The incidence of amniotic fluid embolism was higher with cesarean section, 5,000 of 22,937,000 (22/100,000) than with vaginal delivery, 7,000 of 89,775,000 (8/100,000) (relative risk 2.80, 95% CI 2.70-2.90) (p < 0.0001). The incidence was also higher in women aged 30-39 years, 6,000 of 35,039,000 (17/100,000) than in women aged 15-29 years, 6,000 of 77,673,000 (8/100,000) (relative risk 2.22, 95% CI 2.14-2.30) (p < 0.0001).
The incidence of amniotic fluid embolism has decreased since the early 1990s. The risk is higher with cesarean section and higher in women aged > or =30 years.
确定羊水栓塞的发病率以及剖宫产和年龄对其发病率的影响。
数据来自美国国家医院出院调查。我们调查了1980年至2005年期间美国各地短期非联邦医院出院的、诊断代码为羊水栓塞的患者数量。
1980年至2005年期间，共有112,712,000例分娩，其中12,000例患者（11/100,000）发生羊水栓塞。1993 - 2005年期间羊水栓塞的发病率低于1980 - 1992年（9/100,000对12/100,000）（p < 0.0001）。剖宫产时羊水栓塞的发病率更高，22,937,000例中有5,000例（22/100,000），而阴道分娩时为89,775,000例中有7,000例（8/100,000）（相对风险2.80，95%可信区间2.70 - 2.90）（p < 0.0001）。30 - 39岁女性的发病率也更高，35,039,000例中有6,000例（17/100,000），高于15 - 29岁女性，77,673,000例中有6,000例（8/100,000）（相对风险2.22，95%可信区间2.14 - 2.30）（p < 0.0001）。
自20世纪90年代初以来，羊水栓塞的发病率有所下降。剖宫产时风险更高，且年龄≥30岁的女性风险更高。
