Addeo Raffaele, Caraglia Michele, Del Prete Salvatore
Second University of Naples, Department of Biochemistry and Biophysics, Via Costantinopoli, 16 80138, Naples, Italy.
Expert Opin Investig Drugs. 2009 Mar;18(3):373-8. doi: 10.1517/14712590802680158.
This Italian meeting, co-sponsored by the Italian Southern Oncological Group (GOIM), focused on different aspects of hepatocellular carcinoma (HCC). Topics included epidemiological studies, identification of environmental and genetic risk factors, the molecular mechanisms of pathogenesis, new diagnostic approaches and standard and novel treatment modalities. HCC remains a major health problem worldwide. It is the fifth most common cancer in the world, and the third most common cause of cancer-related death. The goal of HCC management is 'cancer control', reduction in its incidence and mortality as well as improvement in the quality of life of patients with HCC and their families. HCC epidemiology in Campania and the role of hepatitis viruses C and B in the pathogenesis of this cancer were described. Subsequently, state of the art and perspectives on the transduction pathways as therapeutic targets in HCC were evaluated. Another session was about HCC diagnosis by imaging techniques. The last session was dedicated to clinical treatment of this cancer, the role of liver transplantation, surgical resection, loco-regional procedures and systemic treatment modalities. Finally, the final results of the So.Lar. study on the Sorafenib + octreotide long-acting release (LAR) combination were presented.
这次由意大利南部肿瘤学小组（GOIM）共同主办的意大利会议聚焦于肝细胞癌（HCC）的不同方面。主题包括流行病学研究、环境和遗传风险因素的识别、发病机制的分子机制、新的诊断方法以及标准和新型治疗方式。HCC仍然是全球主要的健康问题。它是世界上第五大常见癌症，也是癌症相关死亡的第三大常见原因。HCC管理的目标是“癌症控制”，降低其发病率和死亡率，并改善HCC患者及其家庭的生活质量。描述了坎帕尼亚地区的HCC流行病学以及丙型和乙型肝炎病毒在该癌症发病机制中的作用。随后，评估了作为HCC治疗靶点的转导途径的现状和前景。另一场会议是关于通过成像技术诊断HCC。最后一场会议专门讨论了这种癌症的临床治疗、肝移植、手术切除、局部区域治疗和全身治疗方式的作用。最后，展示了索拉非尼+长效奥曲肽（LAR）联合用药的So.Lar.研究的最终结果。
