AlBanoon Fertility Center, Department of Obstetrics & Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Fertil Steril. 2010 May 1;93(7):2182-8. doi: 10.1016/j.fertnstert.2009.01.066. Epub 2009 Feb 24.
To test the hypothesis that the addition of 6 mg estradiol (E2) valerate either orally or vaginally to progesterone (P) for luteal support, can increase the probability of pregnancy in intracytoplasmic sperm injection (ICSI) cycles using the long agonist protocol.
Prospective open-labeled randomized controlled trial.
Private and university fertility centers.
PARTICIPANT(S): Women undergoing ICSI cycles, with controlled ovarian hyperstimulation using long agonist protocol.
INTERVENTION(S): On embryo transfer day, participants were randomized to receive, only P (group A, n = 90), P along with 6 mg E(2) valerate either orally (group B, n = 90), or vaginally (group C, n = 90) for luteal support.
MAIN OUTCOME MEASURE(S): Clinical pregnancy was the main outcome. luteal serum E(2) and P profiles were the secondary outcomes.
RESULT(S): Highest pregnancy rate was achieved in group C (45.56%), it was significantly higher than A (relative risk 1.52, 95% CI: 1.03 to 2.24). Day 0 (hCG day) E2 levels were similar in the three groups. Group A had lower E2 levels on days 7, 10, and 13 and a higher magnitude of E2 decline on days 7 and 10. Similar levels of luteal E2 were documented in groups B and C. P levels were similar in the three groups.
CONCLUSIONS(S): Addition of 6 mg E(2) valerate to P support may encumber the sharp decline in luteal E(2) level. It may enhance the probability of pregnancy if administered vaginally.
验证假设，即在黄体支持中，孕激素（P）中添加 6 毫克戊酸雌二醇（E2），无论是口服还是阴道给药，都可以提高长激动剂方案的胞浆内精子注射（ICSI）周期中妊娠的可能性。
前瞻性、开放性、随机对照试验。
私人和大学生育中心。
接受 ICSI 周期的妇女，使用长激动剂方案进行控制性卵巢超刺激。
在胚胎移植日，参与者被随机分为三组：仅接受 P（A 组，n=90）、P 加 6 毫克戊酸雌二醇口服（B 组，n=90）或阴道（C 组，n=90）支持黄体。
临床妊娠是主要结果。黄体血清 E2 和 P 谱是次要结果。
C 组（45.56%）的妊娠率最高，显著高于 A 组（相对风险 1.52，95%CI：1.03 至 2.24）。三组的第 0 天（hCG 日）E2 水平相似。A 组在第 7、10 和 13 天的 E2 水平较低，在第 7 和 10 天的 E2 下降幅度较大。B 组和 C 组的黄体 E2 水平相似。三组的 P 水平相似。
在 P 支持中添加 6 毫克戊酸雌二醇可能会阻碍黄体 E2 水平的急剧下降。如果阴道给药，可能会提高妊娠的可能性。
