Darcy Daniel P, Isaacson Jeffry S
Department of Neuroscience, University of California, San Diego School of Medicine, La Jolla, California 92093, USA.
J Neurosci. 2009 Feb 25;29(8):2510-8. doi: 10.1523/JNEUROSCI.5333-08.2009.
Newborn inhibitory neurons migrate into existing neural circuitry in the olfactory bulb throughout the lifetime of adult mammals. While many factors contribute to the maturation of neural circuits, intracellular calcium is believed to play an important role in regulating cell migration and the development of neural systems. However, the factors underlying calcium signaling within newborn neurons in the postnatal olfactory bulb are not well understood. Here, we show that migrating, immature neurons in the olfactory bulb subependymal layer (SEL) undergo spontaneous and depolarization-evoked intracellular calcium transients mediated by high-voltage-activated L-type calcium channels. In contrast to migrating immature neurons in other brain regions, modulation of calcium transients in SEL cells does not alter their rate of migration.
新生抑制性神经元在成年哺乳动物的整个生命周期中迁移到嗅球中现有的神经回路中。虽然许多因素有助于神经回路的成熟,但细胞内钙被认为在调节细胞迁移和神经系统发育中起重要作用。然而,出生后嗅球中新生神经元内钙信号传导的潜在因素尚不清楚。在这里,我们表明,嗅球室管膜下层(SEL)中迁移的未成熟神经元经历由高电压激活的L型钙通道介导的自发和去极化诱发的细胞内钙瞬变。与其他脑区中迁移的未成熟神经元不同,SEL细胞中钙瞬变的调节不会改变它们的迁移速度。