Cerutti I, Chany-Fournier F, Chany C
C R Acad Hebd Seances Acad Sci D. 1977 Feb 21;284(8):697-700.
The degradation of the antiviral state can be delayed in vitro by antimetabolites, when added between 5-7 hours after interferon. We explore in this chronological order whether antiviral resistance induced by Newcastle disease virus (N.D.V.) in vivo could be modified by an antimetabolite. Cycloheximide was selected for this study because of its reversible biological effect and lack of toxicity in our experimental conditions. The model system employed was Syrian Hamsters, using N.D.V. as an interferon inducer and encephalomyocarditis virus (E.M.C.) as a challenge virus. A constant and significant increase in survival of animals treated with N.D.V.+cycloheximide is probably related to a delay in the degradation of the antiviral state and not to interferon superinduction.
当在干扰素作用后5至7小时之间添加抗代谢物时，体外抗病毒状态的降解可被延迟。我们按此时间顺序探究了新城疫病毒（N.D.V.）在体内诱导的抗病毒抗性是否可被一种抗代谢物改变。由于放线菌酮在我们的实验条件下具有可逆的生物学效应且无毒性，因此被选用于本研究。所采用的模型系统是叙利亚仓鼠，使用N.D.V.作为干扰素诱导剂，脑心肌炎病毒（E.M.C.）作为攻击病毒。用N.D.V. +放线菌酮处理的动物存活率持续且显著提高，这可能与抗病毒状态降解的延迟有关，而非与干扰素超诱导有关。
