Kreitzer Faith R, Stella Nephi
Department of Pharmacology, University of Washington, Seattle, WA 98115-7280, USA.
Pharmacol Ther. 2009 May;122(2):83-96. doi: 10.1016/j.pharmthera.2009.01.005. Epub 2009 Feb 25.
Cannabinoids produce a plethora of biological effects, including the modulation of neuronal activity through the activation of CB(1) receptors and of immune responses through the activation of CB(2) receptors. The selective targeting of either of these two receptor subtypes has clear therapeutic value. Recent evidence indicates that some of the cannabinomimetic effects previously thought to be produced through CB(1) and/or CB(2) receptors, be they on neuronal activity, on the vasculature tone or immune responses, still persist despite the pharmacological blockade or genetic ablation of CB(1) and/or CB(2) receptors. This suggests that additional cannabinoid and cannabinoid-like receptors exist. Here we will review this evidence in the context of their therapeutic value and discuss their true belonging to the endocannabinoid signaling system.
大麻素会产生大量生物学效应，包括通过激活CB(1)受体来调节神经元活动，以及通过激活CB(2)受体来调节免疫反应。选择性靶向这两种受体亚型中的任何一种都具有明确的治疗价值。最近的证据表明，一些先前认为是通过CB(1)和/或CB(2)受体产生的大麻素样效应，无论是对神经元活动、血管张力还是免疫反应的影响，在CB(1)和/或CB(2)受体被药物阻断或基因敲除后仍然存在。这表明存在其他大麻素和类大麻素受体。在此，我们将在其治疗价值的背景下回顾这一证据，并讨论它们是否真正属于内源性大麻素信号系统。
