可切除胃肠道间质瘤的管理
Management of resectable gastrointestinal stromal tumor.
作者信息
Chaudhry Umer I, DeMatteo Ronald P
机构信息
Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, Box 203, 1275 York Avenue, New York, NY 10021, USA.
出版信息
Hematol Oncol Clin North Am. 2009 Feb;23(1):79-96, viii. doi: 10.1016/j.hoc.2009.01.001.
Abstract
Gastrointestinal stromal tumor (GIST) is a rare neoplasm that recently has become an intense focus of scientific investigation, as it serves as a model for the molecular therapy for cancer. Although surgery remains the principle treatment of primary localized GIST, imatinib mesylate, a selective inhibitor of KIT protein, achieves dramatic responses in metastatic GIST. Multimodality therapy integrating surgery and molecular therapy has shown promise. This article summarizes the epidemiology, clinicopathologic features, natural history, and clinical management of GIST.
摘要
胃肠道间质瘤（GIST）是一种罕见的肿瘤，近来已成为科学研究的热点，因为它可作为癌症分子治疗的一个模型。虽然手术仍然是原发性局限性GIST的主要治疗方法，但甲磺酸伊马替尼，一种KIT蛋白的选择性抑制剂，在转移性GIST中能产生显著疗效。整合手术和分子治疗的多模式治疗已显示出前景。本文总结了GIST的流行病学、临床病理特征、自然病史及临床管理。
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本文引用的文献
1
Molecular characterization of pediatric gastrointestinal stromal tumors.
Clin Cancer Res. 2008 May 15;14(10):3204-15. doi: 10.1158/1078-0432.CCR-07-1984.
2
Gastrointestinal stromal tumors and leiomyosarcomas.
J Surg Oncol. 2008 Mar 15;97(4):350-9. doi: 10.1002/jso.20970.
3
Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST).
Cancer. 2008 Feb 1;112(3):608-15. doi: 10.1002/cncr.23199.
4
Advances in the treatment of gastrointestinal stromal tumours.
Ann Oncol. 2007 Sep;18 Suppl 10:x20-4. doi: 10.1093/annonc/mdm410.
5
NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines.
J Natl Compr Canc Netw. 2007 Jul;5 Suppl 2:S1-29; quiz S30.
6
Soft tissue sarcoma.
J Natl Compr Canc Netw. 2007 Apr;5(4):364-99. doi: 10.6004/jnccn.2007.0034.
7
Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor.
Ann Surg. 2007 Mar;245(3):347-52. doi: 10.1097/01.sla.0000236630.93587.59.
8
Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced/metastatic GIST.
Ann Surg. 2007 Mar;245(3):341-6. doi: 10.1097/01.sla.0000242710.36384.1b.
9
A review of resistance patterns and phenotypic changes in gastrointestinal stromal tumors following imatinib mesylate therapy.
J Gastrointest Surg. 2007 Jun;11(6):758-66. doi: 10.1007/s11605-007-0150-y.
10
L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition.
Int J Cancer. 2007 Jul 15;121(2):257-64. doi: 10.1002/ijc.22681.
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