Katz Steven C, DeMatteo Ronald P
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
J Surg Oncol. 2008 Mar 15;97(4):350-9. doi: 10.1002/jso.20970.
Only recently has gastrointestinal stromal tumor (GIST) been recognized as the most frequent GI mesenchymal neoplasm. Prior to the use of KIT staining, most GI stromal tumors were identified as leiomyosarcoma (LMS). For primary GIST, surgery remains the principal treatment and adjuvant imatinib may improve outcomes. Multimodality therapy may also be effective in patients with metastatic GIST. In this review, we summarize the epidemiology, clinicopathologic features, natural history, and clinical management of LMS and GIST.
直到最近，胃肠道间质瘤（GIST）才被公认为最常见的胃肠道间叶性肿瘤。在使用KIT染色之前，大多数胃肠道间质瘤被诊断为平滑肌肉瘤（LMS）。对于原发性GIST，手术仍然是主要的治疗方法，辅助使用伊马替尼可能会改善治疗效果。多模式治疗对转移性GIST患者也可能有效。在本综述中，我们总结了LMS和GIST的流行病学、临床病理特征、自然病史及临床管理。
