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曲霉性骨髓炎：前瞻性抗真菌治疗联盟登记处确诊的12例病例回顾

Aspergillus osteomyelitis: review of 12 cases identified by the Prospective Antifungal Therapy Alliance registry.

作者信息

Horn David, Sae-Tia Sutthichai, Neofytos Dionissios

机构信息

Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

Diagn Microbiol Infect Dis. 2009 Apr;63(4):384-7. doi: 10.1016/j.diagmicrobio.2008.12.005. Epub 2009 Feb 26.

DOI:10.1016/j.diagmicrobio.2008.12.005
PMID:19249181
Abstract

A review of 12 patients with proven Aspergillus osteomyelitis was undertaken between July 2004 and October 2007. Aspergillus fumigatus was most commonly identified (n = 9). Voriconazole was commonly administered (11/12; 91.7%), and 9 (75.0%) underwent surgery. Seven (58.3%) responded to treatment, and 12-week mortality was 25.0% (3/12). Survival was improved with surgical intervention (P = 0.05).

摘要

2004年7月至2007年10月期间，对12例确诊为曲霉性骨髓炎的患者进行了回顾性研究。最常鉴定出的是烟曲霉（n = 9）。伏立康唑是常用药物（11/12；91.7%），9例（75.0%）接受了手术。7例（58.3%）对治疗有反应，12周死亡率为25.0%（3/12）。手术干预可提高生存率（P = 0.05）。

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