细胞间黏附分子-1的阻断：一种治疗血管炎的新方法。

Blockade of ICAM-1: a novel way of vasculitis treatment.

作者信息

Xu Youhua, Li Shengnan

机构信息

Department of Pharmacology, Nanjing Medical University, PR China.

出版信息

Biochem Biophys Res Commun. 2009 Apr 17;381(4):459-61. doi: 10.1016/j.bbrc.2009.02.111. Epub 2009 Feb 26.

DOI:10.1016/j.bbrc.2009.02.111

PMID:19249285

Abstract

Vasculitis is becoming more common worldwide, but there is no effective therapeutic method towards this series of disease till now. Intercellular adhesion molecule (ICAM)-1 is one of an important cell adhesion molecules (CAMs) family glycoprotein that plays pivotal role in inflammation process and participates in vasculitis. Blockade of ICAM-1 has been witnessed with its satisfactory effect on inflammatory disease treatment. Therefore, this method may be considered as a novel way towards treatment of vasculitis.

摘要

血管炎在全球范围内正变得越来越普遍，但迄今为止，针对这一系列疾病尚无有效的治疗方法。细胞间黏附分子（ICAM）-1是重要的细胞黏附分子（CAMs）家族糖蛋白之一，在炎症过程中起关键作用并参与血管炎。已证实阻断ICAM-1对炎症性疾病的治疗效果令人满意。因此，这种方法可被视为治疗血管炎的一种新途径。