ICAM - 5——哺乳动物大脑中一种新型的双功能黏附分子。
ICAM-5--a novel two-facetted adhesion molecule in the mammalian brain.
作者信息
Gahmberg Carl G, Tian Li, Ning Lin, Nyman-Huttunen Henrietta
机构信息
Division of Biochemistry, Faculty of Biosciences, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland.
出版信息
Immunol Lett. 2008 May 15;117(2):131-5. doi: 10.1016/j.imlet.2008.02.004. Epub 2008 Mar 10.
Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of adhesion proteins. These proteins bind to leukocyte beta(2)-integrins (CD11/CD18), but ICAM-5 is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at the time of birth, and is located in the soma and dendrites of neurons. It is structurally more complex than the others, and also shows homophilic adhesion. Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission.
细胞黏附对于正常发育和细胞功能至关重要。细胞间黏附分子5（ICAM - 5，端脑糖蛋白）是黏附蛋白ICAM家族的成员。这些蛋白与白细胞β2整合素（CD11/CD18）结合，但ICAM - 5在几个方面具有特殊性。它仅在哺乳动物前脑表达，出生时出现，位于神经元的胞体和树突中。它在结构上比其他成员更复杂，并且还表现出同种型黏附。最近的研究表明，它对于调节大脑中的免疫活性以及神经元突触的发育和信号传递很重要。
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