Caldwell Matthew C, Perfect John R, Carlson Alan N, Proia Alan D
Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27701, USA.
J Cataract Refract Surg. 2009 Mar;35(3):598-602. doi: 10.1016/j.jcrs.2008.08.046.
We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man. The infection was thought to be treated successfully with intravitreal amphotericin B but flared 7 months later following cataract extraction and eventually required explantation of the intraocular lens and therapeutic keratoplasty. The literature regarding this rare infection is reviewed. Candida glabrata, an uncommon ocular pathogen, is being reported with increasing frequency and with a notable predilection for post-keratoplasty eyes. In the 10 reported cases, there is 100% concordance between host and donor tissue cultures. In half the cases, there was a latent period of several months. These infections can be difficult to treat because C glabrata is often resistant to the antifungal agents commonly used to treat Candida albicans.
我们报告了一例57岁男性穿透性角膜移植术后发生光滑念珠菌性眼内炎的病例。感染最初被认为通过玻璃体内注射两性霉素B成功治愈，但在白内障摘除术后7个月复发，最终需要取出人工晶状体并进行治疗性角膜移植。本文回顾了关于这种罕见感染的文献。光滑念珠菌是一种不常见的眼部病原体，其报告频率正在增加，并且明显倾向于感染角膜移植术后的眼睛。在已报告的10例病例中，宿主和供体组织培养结果100%一致。半数病例存在数月的潜伏期。这些感染可能难以治疗，因为光滑念珠菌通常对常用于治疗白色念珠菌的抗真菌药物耐药。
