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机器人辅助腹腔镜根治性子宫切除术及盆腔淋巴结清扫术的短期和长期发病数据

Robot assisted laparoscopic radical hysterectomy and pelvic lymphadenectomy with short and long term morbidity data.

作者信息

Persson Jan, Reynisson Petur, Borgfeldt Christer, Kannisto Paivi, Lindahl Bengt, Bossmar Thomas

机构信息

Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.

出版信息

Gynecol Oncol. 2009 May;113(2):185-90. doi: 10.1016/j.ygyno.2009.01.022. Epub 2009 Feb 28.

Abstract

OBJECTIVE

To evaluate feasibility and morbidity of robot assisted laparoscopic radical hysterectomy.

METHODS

From December 2005 to September 2008 robot assisted laparoscopic radical hysterectomy and pelvic lymphadenectomy was performed on 80 women. Using a prospective protocol, and an active investigation policy for defined adverse events, perioperative, short and long term data were obtained.

RESULTS

Time for surgery (skin to skin) reached 176 and 132 min after 9 and 34 procedures respectively. All tumours were radically removed. Median number of retrieved lymph nodes was 26 (range 15-55). All women had an early follow up (1-3 months) and 43 of eligible 46 women (93%) had a long term follow up (> or =12 months). In 33 of 80 women (41%) the peri/postoperative period was uneventful. The remainder had one or more mainly mild adverse events, most commonly from the vaginal cuff (n=17, 21%) or the lymphatic system (n=16, 20%). The proportion of uneventful cases increased significantly over time. Five women were resutured for dehiscence of the vaginal cuff, two women were reoperated for trocar site hernias and one woman had a ureter stricture that resolved following stent treatment. Eight women (14%) needed 60 days or more to resume spontaneous voiding. One 72-year old woman with disseminated endometrial cancer on autopsy died of pulmonary embolism 31 days after surgery.

CONCLUSIONS

Robot assisted laparoscopic radical hysterectomy is a feasible alternative to conventional laparoscopy and open surgery. Effort should be made to ensure proper closure of the vaginal cuff, trocar sites and to develop nerve sparing techniques.

摘要

目的

评估机器人辅助腹腔镜根治性子宫切除术的可行性及发病率。

方法

2005年12月至2008年9月,对80名女性实施了机器人辅助腹腔镜根治性子宫切除术及盆腔淋巴结清扫术。采用前瞻性方案,并对明确的不良事件进行积极调查,获取围手术期、短期和长期数据。

结果

分别在9例和34例手术后,手术时间(皮肤切开至皮肤缝合)达到176分钟和132分钟。所有肿瘤均被根治性切除。回收淋巴结的中位数为26个(范围15 - 55个)。所有女性均进行了早期随访(1 - 3个月),46名符合条件的女性中有43名(93%)进行了长期随访(≥12个月)。80名女性中有33名(41%)围手术期/术后过程顺利。其余患者发生了一种或多种主要为轻度的不良事件,最常见于阴道断端(n = 17,21%)或淋巴系统(n = 16,20%)。随着时间的推移,顺利病例的比例显著增加。5名女性因阴道断端裂开进行了再次缝合,2名女性因套管针穿刺部位疝进行了再次手术,1名女性出现输尿管狭窄,经支架治疗后缓解。8名女性(14%)需要60天或更长时间才能恢复自主排尿。一名72岁患有弥漫性子宫内膜癌的女性术后31天死于肺栓塞。

结论

机器人辅助腹腔镜根治性子宫切除术是传统腹腔镜手术和开放手术的一种可行替代方法。应努力确保阴道断端、套管针穿刺部位的妥善闭合,并开发保留神经的技术。

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