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食蟹猴的腹部囊尾蚴病

Abdominal cysticercosis in a cynomolgus monkey.

作者信息

Tsubota Kenjiro, Nakatsuji Shunji, Matsumoto Masahiro, Fujihira Shiro, Yoshizawa Katsuhiko, Okazaki Yoshimasa, Murakami Yuichi, Anagawa Akiko, Oku Yuzaburo, Oishi Yuji

机构信息

Toxicologic Pathology, Drug Safety Research Labs., Astellas Pharma Inc., 2-1-6 Kashima Yodogawa-ku, Osaka 532-8514, Japan.

出版信息

Vet Parasitol. 2009 May 12;161(3-4):339-41. doi: 10.1016/j.vetpar.2009.01.024. Epub 2009 Feb 6.

Abstract

Cysticercus tenuicollis, the larval form of Taenia hydatigena, was observed in a 5-year-old male cynomolgus monkey used in a toxicity study for a safety assessment of a pharmaceutical. The animal was born and raised in a primate colony in China. A pale yellow cyst filled with more than 100ml of pale yellow fluid was found in the abdominal cavity in the autopsy. The cyst was found attached to the greater omentum, and it was double layered. Histopathologically, the outer layer was a part of the greater omentum, and the inner layer was the bladder wall of a cysticercus with a well developed scolex. A partial sequence of mitochondrial NADH dehydrogenase subunit 1 showed a high homology to the same region of Taenia hydatigena (1.5-3.3%).

摘要

细颈囊尾蚴是泡状带绦虫的幼虫形式,在一只用于药物安全性评估毒性研究的5岁雄性食蟹猴中被观察到。这只动物在中国的一个灵长类动物饲养群体中出生并长大。尸检时在腹腔中发现一个浅黄色囊肿,充满了超过100毫升的浅黄色液体。该囊肿附着于大网膜,为双层结构。组织病理学检查显示,外层是大网膜的一部分,内层是具有发育良好头节的囊尾蚴的囊壁。线粒体烟酰胺腺嘌呤二核苷酸脱氢酶亚基1的部分序列与泡状带绦虫的相同区域显示出高度同源性(1.5 - 3.3%)。

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