Mili Stavroula, Macara Ian G
Department of Microbiology, Center for Cell Signaling, University of Virginia, HSC, Charlottesville, 22908-0577, USA.
Trends Cell Biol. 2009 Apr;19(4):156-64. doi: 10.1016/j.tcb.2009.02.001. Epub 2009 Feb 27.
Cell polarization relies on the asymmetric organization of cellular structures and activities, and is fundamentally important both during development and for the proper function of most somatic cells. Asymmetries in the distribution and activity of proteins can be achieved through localization of RNA molecules that usually give rise to proteins at specific subcellular sites. It is increasingly appreciated that this is a widely used mechanism affecting protein function at multiple levels. The description of a new RNA localization pathway involving the tumor-suppressor protein APC raises questions regarding coordination between distinct localization pathways and their effects on protein function and cell polarity.
细胞极化依赖于细胞结构和活动的不对称组织，在发育过程以及大多数体细胞的正常功能发挥中都至关重要。蛋白质分布和活性的不对称可通过RNA分子的定位来实现，这些RNA分子通常在特定亚细胞位点产生蛋白质。人们越来越认识到，这是一种在多个层面影响蛋白质功能的广泛使用的机制。一种涉及肿瘤抑制蛋白APC的新RNA定位途径的描述，引发了关于不同定位途径之间的协调及其对蛋白质功能和细胞极性影响的问题。
