Lin Andrew C, Holt Christine E
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Curr Opin Neurobiol. 2008 Feb;18(1):60-8. doi: 10.1016/j.conb.2008.05.004. Epub 2008 May 26.
An increasing body of evidence indicates that local axonal translation is required for growing axons to respond appropriately to guidance cues and other stimuli. Recent studies suggest that asymmetrical synthesis of cytoskeletal proteins mediates growth cone turning and that local translation and retrograde transport of transcription factors mediate neuronal survival. Axonal translation is regulated partly by selective axonal localization of mRNAs and by translation initiation factors and RNA-binding proteins. We discuss possible rationales for local axonal translation, including distinct properties of nascent proteins, precise localization, and axonal autonomy.
越来越多的证据表明，生长中的轴突要对导向线索和其他刺激做出适当反应，就需要局部轴突翻译。最近的研究表明，细胞骨架蛋白的不对称合成介导生长锥转向，转录因子的局部翻译和逆行运输介导神经元存活。轴突翻译部分受mRNA的选择性轴突定位、翻译起始因子和RNA结合蛋白的调控。我们讨论了局部轴突翻译的可能原理，包括新生蛋白质的独特性质、精确定位和轴突自主性。
