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NQO1基因的C609T变异与2型糖尿病患者的颈动脉斑块有关。

The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes.

作者信息

Han Seung Jin, Kang Eun Seok, Kim Hyeong Jin, Kim So Hun, Chun Sung Wan, Ahn Chul Woo, Cha Bong Soo, Nam Moonsuk, Lee Hyun Chul

机构信息

Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.

出版信息

Mol Genet Metab. 2009 May;97(1):85-90. doi: 10.1016/j.ymgme.2009.01.012. Epub 2009 Feb 1.

Abstract

OBJECTIVE

Atherosclerosis in patients with type 2 diabetes has been linked to oxidative stress. NADP[1]:quinone oxidoreductase 1 (NQO1) plays a key role in cellular antioxidant defense. Recent reports suggest that highly expressed and inducible endogenous NQO1 from cardiovascular cells may act as a potential superoxide scavenger. We examined the relationship between the risk of NQO1 C609T polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes.

METHODS

We recruited 601 (Seoul set) and 233 (Koyang set) unrelated patients with type 2 diabetes from independent groups. The C609T variant of NQO1 was genotyped by Taqman RT-PCR. Mean and maximum carotid intima-media thickness (IMT) and carotid artery plaques were measured by high-resolution ultrasonography.

RESULTS

Patients with the T allele exhibited a higher prevalence of atherosclerotic plaques than non-T allele carriers in both sets (Seoul set vs. Koyang set, p=0.021, p=0.023, respectively). After adjusting for age, sex, duration of diabetes, systolic blood pressure, body mass index, current smoking, HDL-cholesterol, LDL-cholesterol and HbA1c, subjects with the T allele had a significantly higher risk of carotid artery plaques (Seoul set vs. Koyang set, OR=1.65, p=0.015; OR=2.00, p=0.037, respectively) than subjects with the CC genotype.

CONCLUSION

These results suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients.

摘要

目的

2型糖尿病患者的动脉粥样硬化与氧化应激有关。烟酰胺腺嘌呤二核苷酸磷酸[1]:醌氧化还原酶1(NQO1)在细胞抗氧化防御中起关键作用。最近的报道表明,心血管细胞中高表达且可诱导的内源性NQO1可能作为一种潜在的超氧化物清除剂。我们研究了NQO1 C609T基因多态性风险与2型糖尿病患者颈动脉粥样硬化之间的关系。

方法

我们从独立组中招募了601名(首尔组)和233名(高阳组)无亲缘关系的2型糖尿病患者。通过Taqman RT-PCR对NQO1的C609T变异进行基因分型。采用高分辨率超声测量平均和最大颈动脉内膜中层厚度(IMT)以及颈动脉斑块。

结果

在两组中,携带T等位基因的患者动脉粥样硬化斑块的患病率均高于非T等位基因携带者(首尔组与高阳组,分别为p = 0.021,p = 0.023)。在调整年龄、性别、糖尿病病程、收缩压、体重指数、当前吸烟情况、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和糖化血红蛋白后,携带T等位基因的受试者患颈动脉斑块的风险显著高于CC基因型受试者(首尔组与高阳组,OR分别为1.65,p = 0.015;OR为2.00,p = 0.037)。

结论

这些结果表明,NQO1的C609T基因多态性与2型糖尿病患者的颈动脉斑块有关。

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