Yan Limin, Xu Dedong, Xiao Ying, Dai Mingming, Wang Ting, Zhuang Xinhong, Wu Kunliang
Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, People's Republic of China.
Department of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, People's Republic of China.
Neuropsychiatr Dis Treat. 2022 Sep 28;18:2211-2217. doi: 10.2147/NDT.S379742. eCollection 2022.
NAD(P)H: Quinone Oxidoreductase 1 gene (NQO1) polymorphism is associated with the risk of cardiovascular disease. This study was designed to investigate the relationship between NQO1 gene polymorphism and ischemic stroke susceptibility in Chinese Han nationality.
One hundred and forty-one patients diagnosed with ischemic stroke and 139 matched control groups were recruited in this study. The polymorphism distribution of locus and locus of NQO1 gene was genotyped via TaqMan assay, and the concentration of Oxidized low-density lipoprotein (ox-LDL) in the blood of the subjects was detected by enzyme linked immunosorbent assay (ELISA). The relationship between the polymorphism distribution and the susceptibility to ischemic stroke was evaluated.
The frequency distribution of the three genotypes of NQO1 between the case group and the control group was statistically significant, and cases carrying CT and TT genotype were less likely to suffer from ischemic stroke. Compared with individuals carrying T allele, C allele carriers have higher risk of ischemic stroke. However, there was no significant difference in frequency distribution among the three genotypes of NQO1 between controls and patients.
The NQO1 C allele may be a novel marker associated with ischemic stroke susceptibility in Chinese Han population. Polymorphism of locus in NQO1 gene may be protective against ischemic stroke risk.
烟酰胺腺嘌呤二核苷酸磷酸（NAD(P)H）：醌氧化还原酶1基因（NQO1）多态性与心血管疾病风险相关。本研究旨在探讨中国汉族人群中NQO1基因多态性与缺血性中风易感性之间的关系。
本研究招募了141例诊断为缺血性中风的患者和139例匹配的对照组。通过TaqMan分析法对NQO1基因的 位点和 位点的多态性分布进行基因分型，并采用酶联免疫吸附测定法（ELISA）检测受试者血液中氧化型低密度脂蛋白（ox-LDL）的浓度。评估多态性分布与缺血性中风易感性之间的关系。
病例组和对照组之间NQO1三种基因型的频率分布具有统计学意义，携带CT和TT基因型的病例患缺血性中风的可能性较小。与携带T等位基因的个体相比，C等位基因携带者患缺血性中风的风险更高。然而，对照组和患者之间NQO1三种基因型的频率分布没有显著差异。
NQO1的C等位基因可能是中国汉族人群中与缺血性中风易感性相关的一个新标记。NQO1基因 位点的多态性可能对缺血性中风风险具有保护作用。
