Valencia University, Valencia, Spain.
Oral Oncol. 2009 Jul;45(7):551-4. doi: 10.1016/j.oraloncology.2009.01.002. Epub 2009 Feb 28.
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe complication seen most frequently in patients on intravenous bisphosphonates treatment for malignant diseases. High potency bisphosphonates are generally implicated and risk factors also include dental extractions. Prevention is of paramount importance. Management is controversial but there is little evidence basis and the consensus is to be conservative. Recent advances in this area are summarised in this concise review.
颌骨骨坏死与双膦酸盐相关（BRONJ）是一种严重的并发症，最常发生在接受静脉内双膦酸盐治疗恶性疾病的患者中。通常与高活性双膦酸盐有关，且危险因素还包括拔牙。预防至关重要。治疗存在争议，但证据基础很少，共识是要保守治疗。本文简要综述了这一领域的最新进展。
