Dierckx Bram, Tulen Joke H M, van den Berg Mijke P, Tharner Anne, Jaddoe Vincent W, Moll Henriette A, Hofman Albert, Verhulst Frank C, Tiemeier Henning
Generation R Study Group, Department of Child and Adolescent Psychiatry, Erasmus MC, Rotterdam 3000 CB, Netherlands.
Psychosom Med. 2009 Apr;71(3):313-21. doi: 10.1097/PSY.0b013e318198a82c. Epub 2009 Feb 27.
To assess the determinants of heart rate (HR) and heart rate variability (HRV) in children. The autonomic nervous system as measured by HR and HRV is considered a biological marker of psychopathology in children.
We examined the relationship of maternal psychopathology with infant HR and HRV. HR was recorded at 14 months in 528 infants. The high-frequency component of HRV was used as an indicator of cardiac vagal modulation. The presence of a lifetime maternal psychiatric diagnosis was assessed with the Composite International Diagnostic Interview. Presence of maternal psychiatric symptoms during pregnancy and 2 months after birth was assessed, using the Brief Symptom Inventory.
A maternal history of a psychiatric disorder was associated with a 0.24-standard deviation (SD) higher mean HR in the infant (beta = 0.24, 95% Confidence Interval (CI) = 0.03, 0.4, p = .025) and a 0.14-SD lower high-frequency power (beta = -0.14, 95% CI = -0.6, -0.03, p = .003). Likewise, postnatal maternal anxiety and depression symptoms were associated with infant mean HR. A 1-point increase in the mean anxiety symptom score was associated with 0.14-SD higher mean HR in the infant (beta = 0.14, 95% CI = 0.05, 0.2, p = .004), and a 1-point increase in mean depression score with a 0.11-SD increase (beta = 0.11, 95% CI = 0.01, 0.2, p = .025). No significant associations of prenatal maternal affective symptoms with infants autonomic functioning were found.
Maternal lifetime psychiatric diagnosis and postnatal psychiatric symptoms are associated with infant autonomic functioning, namely, higher mean HR and lower vagal modulation.
评估儿童心率（HR）和心率变异性（HRV）的决定因素。通过HR和HRV测量的自主神经系统被认为是儿童精神病理学的生物学标志物。
我们研究了母亲精神病理学与婴儿HR和HRV之间的关系。对528名婴儿在14个月时记录了HR。HRV的高频成分被用作心脏迷走神经调制的指标。使用《综合国际诊断访谈》评估母亲一生的精神疾病诊断情况。使用《简要症状量表》评估孕期和产后2个月母亲精神症状的存在情况。
母亲有精神疾病病史与婴儿平均HR高出0.24个标准差（SD）相关（β = 0.24，95%置信区间（CI） = 0.03，0.4，p = 0.025），且高频功率低0.14个SD（β = -0.14，95% CI = -0.6，-0.03，p = 0.003）。同样，产后母亲的焦虑和抑郁症状与婴儿平均HR相关。平均焦虑症状评分增加1分与婴儿平均HR高出0.14个SD相关（β = 0.14，95% CI = 0.05，0.2，p = 0.004），平均抑郁评分增加1分与增加0.11个SD相关（β = 0.11，95% CI = 0.01，0.2，p = 0.025）。未发现产前母亲情感症状与婴儿自主功能有显著关联。
母亲一生的精神疾病诊断和产后精神症状与婴儿自主功能相关，即较高的平均HR和较低的迷走神经调制。
