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人群中痴呆行为和心理症状的患病率、相关因素及病程

Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population.

作者信息

Savva George M, Zaccai Julia, Matthews Fiona E, Davidson Julie E, McKeith Ian, Brayne Carol

机构信息

Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK.

出版信息

Br J Psychiatry. 2009 Mar;194(3):212-9. doi: 10.1192/bjp.bp.108.049619.

Abstract

BACKGROUND

Behavioural and psychological symptoms of dementia (BPSD) are major contributors to the burden of dementia.

AIMS

To describe the prevalence, correlates and course of BPSD in the population of England and Wales.

METHOD

The prevalence of 12 symptoms was estimated in 587 participants with dementia and 2050 participants without dementia as part of a population-based longitudinal study of ageing. The effect of risk factors and the factor structure were estimated using 1782 interviews provided by participants with dementia throughout the study.

RESULTS

Each symptom apart from sleeping problems was more common in the population with dementia. The co-occurrence of the symptoms was explained by a four-factor solution, corresponding to psychosis/apathy, depression/anxiety, irritability/persecution and wandering/sleep problems. Psychosis occurred more frequently with declining cognition. Anxiety and depression were more common in younger individuals and in those with poor self-reported health. Persistence varied between symptoms.

CONCLUSIONS

Behavioural and psychological symptoms of dementia affect nearly all people with dementia. Symptoms co-occur, and the symptoms that affected individuals experience are related to their socio-demographic and clinical characteristics.

摘要

背景

痴呆的行为和心理症状(BPSD)是痴呆负担的主要促成因素。

目的

描述英格兰和威尔士人群中BPSD的患病率、相关因素及病程。

方法

作为一项基于人群的老龄化纵向研究的一部分,对587名痴呆患者和2050名非痴呆患者中12种症状的患病率进行了估计。使用痴呆患者在整个研究过程中提供的1782份访谈资料,对危险因素的影响和因素结构进行了估计。

结果

除睡眠问题外,每种症状在痴呆人群中更为常见。症状的共现可由一个四因素模型解释,分别对应精神病/淡漠、抑郁/焦虑、易激惹/被害妄想和徘徊/睡眠问题。精神病在认知功能下降时更频繁出现。焦虑和抑郁在年轻人以及自我报告健康状况较差的人群中更为常见。不同症状的持续时间各不相同。

结论

痴呆的行为和心理症状几乎影响所有痴呆患者。症状会同时出现,且受影响个体所经历的症状与其社会人口统计学和临床特征有关。

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