Ishitsuka Yoichi, Moriuchi Hiroshi, Yang Changqing, Golbidi Saeid, Irikura Mitsuru, Irie Tetsumi
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan.
Biol Pharm Bull. 2009 Mar;32(3):500-3. doi: 10.1248/bpb.32.500.
To determine whether or not a "bolus injection" of soybean-based fat emulsion (SFE), which contains oleic acid (OA), a potent lung-toxic unsaturated C-18 fatty acid, can induce pulmonary dysfunction, we examined the effect of SFE injection on the partial oxygen pressure of arterial blood (Pao2) and pulmonary vascular permeability. In addition, we compared the effect of an injection of SFE with that of OA, soybean oil (a source of SFE), emulsified OA and C-18 fatty acids. Bolus injection of SFE (0.3-4.8 ml/kg) had little effect on Pao2) and pulmonary vascular permeability. Injection of an equivalent amount of OA, on the other hand, significantly decreased Pao2 and increased pulmonary vascular hyper-permeability. This decrease in Pao2 was attenuated by emulsification. Unemulsified soybean oil also induced a decrease in Pao2, although the effect was weaker than that of OA. Other unsaturated C-18 fatty acids (linoleic and linolenic acid) induced a decrease in Pao2 as potent as OA while stearic acid, a C-18 saturated fatty acid, had little effect. Although we did not observe pulmonary toxicity as a result of "bolus injection" of SFE, the chemical form, for example, emulsification and the degree of saturability of the carbon chain, seems to influence the pulmonary toxicities of lipids and fatty acids. Furthermore, the potent pulmonary toxicity of OA seems to depend not only on pulmonary vascular embolization but also pharmacological and/or inflammation-inducing properties.
为了确定含有油酸（OA）（一种具有肺毒性的不饱和C-18脂肪酸）的大豆基脂肪乳剂（SFE）“大剂量注射”是否会导致肺功能障碍，我们研究了注射SFE对动脉血氧分压（Pao2）和肺血管通透性的影响。此外，我们比较了注射SFE与注射OA、大豆油（SFE的一种来源）、乳化OA和C-18脂肪酸的效果。大剂量注射SFE（0.3 - 4.8 ml/kg）对Pao2和肺血管通透性影响不大。另一方面，注射等量的OA会显著降低Pao2并增加肺血管高通透性。这种Pao2的降低通过乳化作用而减弱。未乳化的大豆油也会导致Pao2降低，尽管其效果比OA弱。其他不饱和C-18脂肪酸（亚油酸和亚麻酸）导致Pao2降低的程度与OA相当，而C-18饱和脂肪酸硬脂酸几乎没有影响。尽管我们未观察到SFE“大剂量注射”导致的肺毒性，但化学形式，例如乳化以及碳链的饱和程度，似乎会影响脂质和脂肪酸的肺毒性。此外，OA强大的肺毒性似乎不仅取决于肺血管栓塞还取决于药理和/或炎症诱导特性。
