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主动特异性免疫疗法与免疫化学疗法在肺癌和结肠癌治疗中的应用

Active specific immunotherapy and immunochemotherapy in the treatment of lung and colon cancer.

作者信息

Hollinshead A

机构信息

Department of Medicine, George Washington Medical Center, Washington, D.C. 20037.

出版信息

Semin Surg Oncol. 1991 Jul-Aug;7(4):199-210. doi: 10.1002/ssu.2980070405.

Abstract

In this seminar, we describe 1) the immunogen TAA used for lung cancer immunotherapy and the immunogen TAA used for colon cancer immunotherapy, 2) the methods used in the administration of these immunogens in clinical trials of specific active TAA immunotherapy, 3) the results of clinical trials of specific active immunotherapy for lung cancer and for colon cancer patients, 4) the results of immune response monitoring evaluations, and what they indicate, and 5) the way in which certain drugs, selected for their action in the immune system, may be synergistic with specific active TAA immunotherapy, in combination therapy, especially for resected patients of later stages.

摘要

在本次研讨会上,我们将描述:1)用于肺癌免疫治疗的免疫原性肿瘤相关抗原(TAA)以及用于结肠癌免疫治疗的免疫原性TAA;2)在特异性活性TAA免疫治疗的临床试验中施用这些免疫原的方法;3)针对肺癌和结肠癌患者的特异性活性免疫治疗的临床试验结果;4)免疫反应监测评估的结果及其所表明的情况;以及5)某些因其在免疫系统中的作用而被选定的药物在联合治疗中,特别是对晚期切除患者,可能与特异性活性TAA免疫治疗产生协同作用的方式。

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