McFetridge Lynne, McMorrow Aoife, Morrison Patrick J, Shields Michael D
Royal Belfast Hospital for Sick Children, Queens University Belfast, Grosvenor Road, Belfast BT12 6BA, UK.
Ulster Med J. 2009 Jan;78(1):7-9.
Surfactant deficiency and the resultant respiratory distress syndrome (RDS) seen in preterm infants is a major cause of respiratory morbidity in this population. Until recently, the contribution of surfactant to respiratory morbidity in infancy was limited to the neonatal period. It is now recognised that inborn errors of surfactant metabolism leading to surfactant dysfunction account for around 10% of childhood interstitial lung disease (chILD). These abnormalities can be detected by blood sampling for mutation analysis, thereby avoiding the need for lung biopsy in some children with chILD.
表面活性剂缺乏以及早产儿中由此产生的呼吸窘迫综合征（RDS）是该人群呼吸疾病的主要原因。直到最近，表面活性剂对婴儿期呼吸疾病的影响还仅限于新生儿期。现在人们认识到，导致表面活性剂功能障碍的表面活性剂代谢先天性缺陷约占儿童间质性肺病（chILD）的10%。这些异常情况可通过采集血样进行突变分析来检测，从而避免了一些chILD患儿进行肺活检的必要性。
