Micelli Ferrari Tommaso, Leozappa Marco, Lorusso Massimo, Epifani Enrico, Micelli Ferrari Luisa
UOC Oculistica, Ospedale Generale Regionale F. Miulli, Acquaviva delle Fonti, Bari - Italy.
Eur J Ophthalmol. 2009 Mar-Apr;19(2):295-7. doi: 10.1177/112067210901900221.
To describe a case of keratitis caused by the Gram-negative Escherichia coli, treated with UVA-riboflavin cross linking.
Case report.
A 78-year-old woman with diabetes presented with a 1-week history of pain, photophobia, foreign body sensation, and lacrimation in the right eye. The patient underwent topical and systemic antimicrobial therapy, without improvement. The authors treated the patient with riboflavin and corneal UVA crosslinking, with the aim to promote healing of the ulceration. One day after the procedure, the corneal ulceration was covered by cicatricial tissue, and the patient reported a significant improvement in symptoms. One month after the treatment, corneal edema was almost completely resolved, corneal ulceration was healed, and the painful symptoms of the patient had disappeared.
UVA-riboflavin crosslinking can be useful for the treatment of corneal ulceration unresponsive to medical treatment.
描述1例由革兰氏阴性大肠杆菌引起的角膜炎病例，采用紫外线A-核黄素交联治疗。
病例报告。
一名78岁糖尿病女性患者，右眼出现疼痛、畏光、异物感和流泪症状1周。患者接受了局部和全身抗菌治疗，但无改善。作者采用核黄素和角膜紫外线A交联治疗该患者，旨在促进溃疡愈合。治疗后一天，角膜溃疡被瘢痕组织覆盖，患者报告症状明显改善。治疗1个月后，角膜水肿几乎完全消退，角膜溃疡愈合，患者疼痛症状消失。
紫外线A-核黄素交联可用于治疗药物治疗无效的角膜溃疡。
