Asuquo M E, Ogunkeyede A, Bassey E E, Ebughe G
Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria.
Ann Afr Med. 2008 Sep;7(3):98-101. doi: 10.4103/1596-3519.55670.
BACKGROUND/OBJECTIVE: Kaposi sarcoma (KS) is now the most frequently reported malignant skin tumour in some areas of Africa and was endemic in Africa before the advent of the human immunodeficiency virus (HIV) infection. The prevalence has increased with the emergence of HIV infection. The objective of this report is to describe the frequency, current clinical pattern, and anatomic distribution of KS in Calabar, south-eastern Nigeria and compare this with total malignant skin tumour.
All the patients with histologic diagnosis of KS presenting to the University of Calabar Teaching Hospital from January 2005 and December 2006 were analyzed as part of the wider study of malignant skin tumorus. Diagnosis of HIV was based upon enzyme linked immunosorbent assay.
In our study, there were 11 patients (7 males and 4 females), with a male: female ratio of 1.75:1. This was the commonest malignant skin tumor (38%) followed by squamous cell carcinoma (SCC) (34.5%) and the age ranged from 21-60 years (mean 42.9 years). Nine patients (81.8%) were HIV positive including the 4 females (age ranged from 21-45 years) and 2 (18.2%) HIV negative, aged 59 and 60 years. The lower limb was the commonest site (50%). Atypical lesions involved the eyelids/nose and penis.
KS is now the commonest malignant skin tumour in our region with the HIV related KS as the commonest clinical type. Successful prevention and treatment of HIV infection would reduce the prevalence of this tumour.
背景/目的：卡波西肉瘤（KS）目前是非洲一些地区报告最频繁的恶性皮肤肿瘤，在人类免疫缺陷病毒（HIV）感染出现之前在非洲呈地方性流行。随着HIV感染的出现，其患病率有所增加。本报告的目的是描述尼日利亚东南部卡拉巴尔KS的发病率、当前临床模式和解剖分布，并将其与全部恶性皮肤肿瘤进行比较。
作为更广泛的恶性皮肤肿瘤研究的一部分，对2005年1月至2006年12月在卡拉巴尔大学教学医院就诊的所有经组织学诊断为KS的患者进行了分析。HIV诊断基于酶联免疫吸附测定。
在我们的研究中，有11例患者（7例男性和4例女性），男女比例为1.75:1。这是最常见的恶性皮肤肿瘤（38%），其次是鳞状细胞癌（SCC）（34.5%），年龄范围为21 - 60岁（平均42.9岁）。9例患者（81.8%）HIV阳性，包括4例女性（年龄范围为21 - 45岁），2例（18.2%）HIV阴性，年龄分别为59岁和60岁。下肢是最常见的部位（50%）。非典型病变累及眼睑/鼻子和阴茎。
KS现在是我们地区最常见的恶性皮肤肿瘤，与HIV相关的KS是最常见的临床类型。成功预防和治疗HIV感染将降低该肿瘤的患病率。
