[导致病毒ECH011对受体衰变加速因子（CD55）亲和力丧失的点突变图谱]
[Mapping of point mutations leading to loss of virus ECH011 affinity for receptor DAF (CD55)].
作者信息
Rezaĭkin A B, Novoselov A B, Fadeev F A, Sergeev A G, Lebedev S B
出版信息
Vopr Virusol. 2009 Jan-Feb;54(1):41-4.
PMID:19253731
Abstract
Comparative sequence of the structural part of genomes pf the original daf+ clone and two derived daf- mutant clones (101 and 103) was analyzed to map mutations responsible for the loss of affinity for the receptor glycoprotein DAF (CD55). The obtained nucleotide sequences (EU167520, EU167521, EU167522) were deposited in the GenBank. There were single point mutations causing amino acid changes in VP2 protein: S145 --> N in clone 101 and G162 --> E in clone 103.
摘要
分析了原始daf+克隆以及两个衍生的daf-突变克隆（101和103）基因组结构部分的比较序列，以定位导致对受体糖蛋白DAF（CD55）亲和力丧失的突变。所获得的核苷酸序列（EU167520、EU167521、EU167522）已存入GenBank。存在导致VP2蛋白氨基酸变化的单点突变：克隆101中S145→N，克隆103中G162→E。
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