Kazennova E V
Vopr Virusol. 2009 Jan-Feb;54(1):45-8.
The review presents data on the use of a single prophylactic dose of nevirapine at labor given to a mother at the onset of labor in HIV-infected women and neonatal infants within 72 hours after birth in the absence of chemoprophylaxis with antiviral agents during pregnancy. The administration of nevirapine is shown to result in the occurrence of resistance mutations, most of which can be identified only if superfine methods are applied. Whether nevirapine may be used for chemoprophylaxis of the vertical transmission of the virus in Russia is discussed.
该综述介绍了在分娩时给感染艾滋病毒的孕妇单次预防性服用奈韦拉平的数据，以及在孕期未使用抗病毒药物进行化学预防的情况下，在出生后72小时内给新生儿婴儿使用奈韦拉平的数据。结果表明，服用奈韦拉平会导致耐药性突变的发生，其中大多数只有采用超精细方法才能识别。文中还讨论了在俄罗斯奈韦拉平是否可用于预防病毒的垂直传播。
