Sutipornpalangkul Werasak, Unchen Supeenun, Sanvarinda Yupin, Chantharaksri Udom
Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2009 Feb;92(2):229-35.
It is believed that the oxidatively modified lipoproteins play a critical role in activating platelets and is a contributing factor in the etiology of a number of cardiovascular-related diseases.
Identify the active component(s) of oxidized LDL that initiated shape change in plasma-free human platelets prepared by a gel filtration method Material and Method: Shape change parameter of platelets was monitored following exposure platelets to LDL, copper sulfate-oxidized LDL, and different types of lipids extracted of the corresponding LDL.
Oxidized LDL, but not native LDL, increased the shape-change parameter in a concentration-dependent manner Specifically, phosphatidyl serine from oxidized LDL was responsible for this effect.
Oxidized phospholipids generated during the oxidative modification of LDL are likely to be the active components responsible for changes in platelet function.
据信，氧化修饰的脂蛋白在激活血小板中起关键作用，并且是许多心血管相关疾病病因中的一个促成因素。
鉴定氧化型低密度脂蛋白（ox-LDL）中能引发通过凝胶过滤法制备的无血浆人血小板发生形态变化的活性成分。材料与方法：在将血小板暴露于低密度脂蛋白（LDL）、硫酸铜氧化型低密度脂蛋白以及从相应低密度脂蛋白中提取的不同类型脂质后，监测血小板的形态变化参数。
氧化型低密度脂蛋白而非天然低密度脂蛋白以浓度依赖的方式增加形态变化参数。具体而言，氧化型低密度脂蛋白中的磷脂酰丝氨酸导致了这种效应。
低密度脂蛋白氧化修饰过程中产生的氧化磷脂可能是导致血小板功能变化的活性成分。
